Intravital microscopy facilitates dynamic three-dimension imaging of various biological processes at the cellular level.
This technique is employed in living animals in vivo, allowing scientists to directly confirm hypotheses gained via in vitro or ex vivo observations performed in a range of natural physiological in vivo microenvironments.
A key benefit to the utilization of intravital microscopy is the potential to set up experiments that allow the observation of changes in the living tissue of a living animal over a period of time.
Intravital microscopy is ideal for the repetitive monitoring of dynamic phenotype changes.
It can also be used to enable the in vivo visualization of dynamic cellular and molecular mechanisms — for example, the investigation of cell subpopulations, cell differentiation and the dynamic remodeling of imaging targets.
The longitudinal in vivo imaging of dynamic phenotype changes inside a living body can be achieved at the cellular level via Intravital microscopy.
The utilization of repetitive intravital imaging of cellular-level tissue remodeling and dynamics inside the living body in vivo offers new and increased insight into a number of human disease development processes. These include:
- Dynamic changes occurring in acute injury models — for example, immune cell recruitment to irritated spot and immune cell dynamics in LPS-induced sepsis
- Dynamic changes occurring in chronic disease models — for example, phenotype changes in liver and lung fibrosis models as well as phenotype changes in MCD (methionine and choline deficient)-diet induced NAFLD and NASH (non-alcoholic fatty liver and non-alcoholic steatohepatitis)
- Dynamic changes occurring in tumor models — such as tumor cell dissociation, growth or metastasis, formation of circulating tumor cells and changes in vascular morphology and permeability
- Dynamic changes occurring in brain disease models — for example changes in BBB penetration, changes in pericyte coverage, tissue cell phagocytosis and apoptosis, changes in target accumulation in brain tissue, changes in cortical capillaries, vascular permeability and vessel diameter, as well as immune cell recruitment to inflammatory or damaged spots
Image Credit: IVIM Technology
About IVIM Technology-2.jpg "Using IVIM Technology Inc.’s IntraVital Microscopy system for repetitive intravital imaging 3")
IVIM Technology was founded based on the innovative technology of IntraVital Microscopy (IVM) developed by the Korea Advanced Institute of Technology (KAIST).
IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up living tissue in vivo.
With this technique, it is possible to distinguish an individual cell among a large number of cells in various organs, which is not possible with conventional biomedical imaging technologies such as MRI or CT, and to track the movement of each cell in three dimensions in real-time.
It is also possible to simultaneously image living cells in living organs, surrounding microenvironments, and molecules such as proteins which is impossible with conventional tissue analysis technology.
Furthermore, this enables us to analyze the in vivo efficacy of new biopharmaceuticals such as immunological, cell, gene, and antibody therapeutic agents acting in real living organisms at the cellular level which is the basic structural and functional unit of life.
The world’s first All-in-One microscopy (IVM) platform developed by IVIM Technology explores the interactions among numerous cells inside the living organisms and will be the next generation high-tech imaging equipment to elucidate the complex processes of human diseases.
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