Saturday, June 25, 2022
No Result
View All Result
Medical Finance
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
No Result
View All Result
Medical Finance
No Result
View All Result
Home News

UI neuroscientists identify fundamental biochemical mechanism underlying memory storage

by Medical Finance
in News
KHN’s ‘What the Health?’: FDA takes center stage
9
SHARES
105
VIEWS
Share on FacebookShare on Twitter

A University of Iowa neuroscience research team has identified a fundamental biochemical mechanism underlying memory storage and has linked this mechanism to cognitive deficits in mouse models of Alzheimer’s Disease and Related Dementias.

While working to understand how memories are formed and stored in the brain, the team identified a novel protein folding mechanism in the endoplasmic reticulum that is essential for long term memory storage. They further demonstrated that this mechanism is impaired in a tau-based mouse model of Alzheimer’s disease and that restoring this protein folding mechanism reverses memory impairment in this mouse model for the study of dementia. The findings are published in the March 23 issue of the journal Science Advances.

The team was led by Snehajyoti Chatterjee, PhD, a research associate in the lab of Ted Abel, PhD, Director of the Iowa Neuroscience Institute and chair and DEO of the UI Department of Neuroscience and Pharmacology. The Abel lab has previously shown that the Nr4a family of transcription factors is essential for long term memory consolidation. This study identified chaperone proteins in the endoplasmic reticulum, which are regulated by Nr4a.

“The role of protein folding machinery in long term memory has been overlooked for decades,” Chatterjee says. “We know that gene expression and protein synthesis are essential for long term memory consolidation and following learning a large number of proteins are synthesized. For proteins to be functionally active they need to be folded correctly. Our work demonstrates the conceptual idea that these chaperone proteins are the ones that actually fold the proteins to impact synaptic function and plasticity.”

The team also used gene therapy to reactivate the chaperone protein in a mouse model and found that the memory deficit was reversed, confirming that the protein folding machinery acts as a molecular switch for memory.

Identifying this protein folding mechanism is a crucial step toward understanding how memories are stored and what goes wrong in diseases associated with memory impairment. Even though we are not yet at a point of translating this to patient care, understanding this pathway is essential to one day being able to prevent and treat neurodegenerative disease.”


Ted Abel, PhD, Director, Iowa Neuroscience Institute

Source:

University of Iowa Health Care

Journal reference:

Chatterjee, S., et al. (2022) Endoplasmic reticulum chaperone genes encode effectors of long-term memory. Science Advances. doi.org/10.1126/sciadv.abm6063.

Total
0
Shares
Share 0
Tweet 0
Pin it 0
Share 0
Medical Finance

Medical Finance

Related Posts

PhoreMost and POLARISqb announce a multi-target collaboration to investigate next-generation cancer therapies

Therapeutic in vivo synthetic chemistry used to make anticancer drugs

by Medical Finance
June 25, 2022
0

An international research group at the RIKEN Cluster for Pioneering Research (CPR) has successfully treated cancer in mice using metal...

What are the benefits of Irish Life Sciences’ new 2.2 mL square well ‘V’ bottom plate?

Olympus Scientific Solutions is now EVIDENT!

by Medical Finance
June 25, 2022
0

Olympus Corporation (“Olympus”) announced the completion of the separation of its Scientific Solutions business to a wholly-owned subsidiary, Evident Corporation...

PhoreMost and POLARISqb announce a multi-target collaboration to investigate next-generation cancer therapies

UiO researchers find 13 special genes related to epigenetic changes in cancer samples

by Medical Finance
June 25, 2022
0

Abnormal epigenetic changes are observed in the development of multiple types of cancer. Researchers at Centre for Molecular Medicine Norway...

Study: Growing Health - Why Agriculture is Vital to the Health of People and the Planet. Image Credit: Andrii Yalanskyi/Shutterstock

The role of agriculture in health

by Medical Finance
June 25, 2022
0

Agriculture is a key occupation for human life, health, and well-being. It refers to the science of cultivation, growing crops,...

New research focuses on improving the manufacturing process of lab-grown tissue from cells

Cell Guidance Systems and Manchester BIOGEL collaborate to launch PODS-PeptiGels for 3D cell culture

by Medical Finance
June 25, 2022
0

PODS-PeptiGels combine two stand-out technologies in single customisable cell culture environment Provides researchers with a predictable and controlled system, with...

What are the benefits of Irish Life Sciences’ new 2.2 mL square well ‘V’ bottom plate?

Scientific solutions business splits from global medtech company

by Medical Finance
June 25, 2022
0

Olympus Corporation (“Olympus”) announced the completion of the separation of its Scientific Solutions business to a wholly-owned subsidiary, Evident Corporation...

Next Post
Study: Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation In Airway Epithelial Cells. Image Credit: Corona Borealis Studio / Shutterstock.com

Researchers investigate Galectin-9 as a new treatment target for COVID-19

Study: Risk of Myocarditis and Pericarditis Following BNT162b2 and mRNA-1273 COVID-19 Vaccination. Image Credit: Teeradej / Shutterstock.com

Study evaluates risk estimates of myocarditis and pericarditis from mRNA-1273 and BNT162b2 vaccines

0 0 votes
Article Rating
Subscribe
Login
Notify of
guest
guest
0 Comments
Inline Feedbacks
View all comments

Support

  • Contact
  • Disclaimer
  • Home
  • Privacy Policy
  • Terms And Conditions

Categories

  • Coronavirus
  • Insights From Industry
  • Interviews
  • Mediknowledge
  • News
  • Thought Leaders
  • Whitepapers

More News

  • Study: Clinical manifestations and disease severity of SARS-CoV-2 infection among infants in Canada. Image Credit: Prostock-studio/Shutterstock
    Study explores SARS-CoV-2 manifestations and related hospitalization in infants
  • Study: An ensemble prediction model for COVID-19 mortality risk. Image Credit: Adao/Shutterstock
    Machine learning model for prediction of COVID-19 patient mortality risk
  • Home
  • Privacy Policy
  • Contact
  • Disclaimer
  • Terms And Conditions

© 2022 Medical Finance - Latest Financial and Business News

No Result
View All Result
  • Interviews
  • Mediknowledge
  • News
  • Insights From Industry
  • Coronavirus
  • Thought Leaders
  • Whitepapers
wpDiscuz
0
0
Would love your thoughts, please comment.x
()
x
| Reply