Friday, July 1, 2022
No Result
View All Result
Medical Finance
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
No Result
View All Result
Medical Finance
No Result
View All Result
Home News

UH researchers receive grant for developing new imaging technique to peer into ribosomes

by Medical Finance
in News
Ocean living microbes make oxygen in the dark
9
SHARES
101
VIEWS
Share on FacebookShare on Twitter

Two University of Houston researchers are developing a type of spectroscopy to help understand how ribosomes make proteins deep within cells, the discovery of which could potentially guide drug design to treat cancers and viral infections. Spectroscopy measures the interaction between light and matter to determine characteristics and volume of cellular matter.

In cellular biology, ribosomes are work horses, veritable factories inside cells, whose job is to make proteins. The instructions that tell the ribosome how to work come from messenger RNA, which contains codes on making proteins, actually called codons. One mistake in defining an upstream codon will be propagated to the rest of the messenger like the domino effect, which spells disaster to the cell.

During protein assembly, the ribosome must be precise in moving from one codon to the next, a process known as translocation. On the other hand, many viruses contain genomic sequences that are designed to slip on certain codons to re-define the protein composition after that codon, in a process called frameshifting.

We are developing a multiplexed super-resolution force spectroscopy to investigate high-fidelity and frameshifting translocations.”


Yuhong Wang, professor of biology and biochemistry

Wang and Shoujun Xu, professor of chemistry, received a $1.2 million grant from the National Institute of General Medical Sciences to support their research.

“We will measure the power strokes from elongation factors (EF-G) and their mutants, which are the enzymes to interact with ribosome during translocation, on normal and viral mRNA sequences and in the presence of antibiotics,” said Xu. “Our research will provide new methodology that can be applied to other biological systems.”

Scientifically, the team is building a new model of ribosome translocation with sub-codon steps and providing potential drug targets for related diseases.

“For example, by tuning down and up the EF-G’s activity in cancer cells and low-functioning neuron cells, the diseases can be treated, anti-viral drugs can be designed that only target the specific viral frameshifting motifs,” said Wang.

Total
0
Shares
Share 0
Tweet 0
Pin it 0
Share 0
Medical Finance

Medical Finance

Related Posts

Researchers explore novel strategy to improve the reprogramming efficiency of human fibroblasts

Novel approach pinpoints genetic variants involved in congenital heart disease

by Medical Finance
July 1, 2022
0

Nearly 1 percent of all children are born with congenital heart disease-;a range of potentially life-threatening problems with the structure...

New mathematical model can calculate the risk of resistance evolution for drug pairs

Antibiotic treatment after birth affects a newborn’s gut microbiome

by Medical Finance
July 1, 2022
0

Treating babies with antibiotics in the first week of life is linked with a decrease in healthy bacteria necessary amongst...

Combing Raman spectroscopy and chemometrics for estimating post-mortem interval in human remains

Study shows link between oral microbiome and naturally occurring alveolar bone loss

by Medical Finance
July 1, 2022
0

It is becoming increasingly clear that the human microbiome – the collection of bacteria, viruses and fungi that live on...

Study: Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes. Image Credit: Naeblys / Shutterstock

Mosaic-8 RBD-nanoparticles show promise against current and future SARS-CoV-2 variants

by Medical Finance
July 1, 2022
0

A recent study posted to the bioRxiv* preprint server supports using mosaic sarbecovirus receptor-binding domain (RBD)-nanoparticles to discover therapeutic pan-variant and...

Nutritional components hold promise for improving the health and well-being of adults

New study investigates the epigenetic drift of time passing

by Medical Finance
July 1, 2022
0

A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, "Time makes...

TetraScience announces 300% ARR growth and 2021 achievements; prepares for next phase of growth

Crystal structure of a human endogenous reverse transcriptase revealed

by Medical Finance
June 30, 2022
0

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target,...

Next Post
Researchers unravel how parent’s gene impact the behavior of children

Researchers unravel how parent's gene impact the behavior of children

Scientists shed light on placenta’s role in transferring vitamin D to fetus during pregnancy

Scientists shed light on placenta's role in transferring vitamin D to fetus during pregnancy

0 0 votes
Article Rating
Subscribe
Login
Notify of
guest
guest
0 Comments
Inline Feedbacks
View all comments

Support

  • Contact
  • Disclaimer
  • Home
  • Privacy Policy
  • Terms And Conditions

Categories

  • Coronavirus
  • Insights From Industry
  • Interviews
  • Mediknowledge
  • News
  • Thought Leaders
  • Whitepapers

More News

  • Accident Injury Information Report Health Rawpixel.com ac5524c1031e4229bc369a9a2a504d1c 620x480
    Biden administration’s rapid-test rollout doesn’t easily reach those who need it most
  • The RapidPick SP in an Anaerobic Chamber. Image Credit: Hudson Robotics
    Lab Automation for Biome Research
  • Home
  • Privacy Policy
  • Contact
  • Disclaimer
  • Terms And Conditions

© 2022 Medical Finance - Latest Financial and Business News

No Result
View All Result
  • Interviews
  • Mediknowledge
  • News
  • Insights From Industry
  • Coronavirus
  • Thought Leaders
  • Whitepapers
wpDiscuz
0
0
Would love your thoughts, please comment.x
()
x
| Reply