Saturday, May 21, 2022
No Result
View All Result
Medical Finance
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
No Result
View All Result
Medical Finance
No Result
View All Result
Home Coronavirus

The zoonotic potential of epidemic porcine deltacoronavirus

by Medical Finance
in Coronavirus
Study: Porcine Deltacoronaviruses: Origin, Evolution, Cross-Species Transmission and Zoonotic Potential. Image Credit: SGr / Shutterstock
9
SHARES
103
VIEWS
Share on FacebookShare on Twitter

Coronaviruses (CoVs) are single-stranded, positive-sense Ribonucleic Acid (RNA) viruses that belong to the Coronaviridae family’s Orthocoronavirinae subfamily. Alphacoronavirus (α-CoV), Betacoronavirus (β-CoV), Gammacoronavirus (ϒ-CoV), and Deltacoronavirus (δ-CoV) are the four genera in which they are categorised.

Coronaviruses are significant human and animal pathogens that cause a variety of diseases. Deltacoronaviruses and gammacoronaviruses primarily infect birds with some mammalian spillover, whereas alphacoronaviruses and betacoronaviruses primarily infect mammals.

During virological monitoring in southern China between 2005 and 2006, deltacoronaviruses were found in the rectal swabs of mammalian species in wet markets, including Asian leopard cats and Chinese ferret badgers.

In Hong Kong, the prototype porcine deltacoronavirus (PDCoV) HKU15 strain was identified in 2012. However, it was not discovered to have pathogenic potential until 2014, when it was found to be the source of pig diarrhea epidemics, which began on numerous farms in Ohio and then spread across the United States (US) and around the world.

In both gnotobiotic (living in germ-free conditions) and conventional pigs, PDCoV infects intestinal epithelial cells, causing severe watery diarrhea, vomiting, and dehydration. Other swine enteric CoVs, such as porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis (TGEV) virus, cause clinical symptoms similar to those caused by PDCoV. 

The present state of knowledge about the genesis, evolution, cross-species transmission, and zoonotic potential of PDCoV is the subject of a review published in the journal Pathogens, which was conducted in a combined effort by researchers from Heilongjiang Bayi Agricultural University and Ohio State University.

Study: Porcine Deltacoronaviruses: Origin, Evolution, Cross-Species Transmission and Zoonotic Potential. Image Credit: SGr / Shutterstock

Study: Porcine Deltacoronaviruses: Origin, Evolution, Cross-Species Transmission and Zoonotic Potential. Image Credit: SGr / Shutterstock

The origin of PDCoV

The International Committee on Taxonomy of Viruses (ICTV) first recognized the Deltacoronavirus genus in 2012, following the identification of three novel avian coronaviruses (bulbul CoV HKU11, thrush CoV HKU12, and munia CoV HKU13) [6] and seven other novel δ-CoVs (porcine CoV HKU15, white-eye CoV HKU16, sparrow CoV HKU17, magpie robin CoV HKU18, night heron CoV HKU19, wigeon CoV HKU20, and common moorhen CoV HKU21) of birds or pigs. The replicase polyprotein gene of PDCoV HKU15 is interestingly connected to the deltacoronavirus discovered in 2006 in Chinese ferret badgers at wet markets. HKU15’s polyprotein, spike (S) protein, envelop (E) protein, membrane (M) protein, non-structure protein 6 (NS6), nucleocapsid (N) protein, and non-structure protein 7 (NS7) genes had 98.70% nucleotide identity with those of the δ-CoV identified in an Asian leopard cat.

More notably, a recent retrospective investigation in Anhui Province, China, showed the prevalence of PDCoV in diarrheic pigs as early as 2004.

Likely origin and routes of cross-species transmission of PDCoV. The red dashed line indicates potential, but unknown, transmission of δ-CoVs from avian to mammalian species; the blue dashed line indicates potential transmission of PDCoV based on epidemiology or experimental studies.

Likely origin and routes of cross-species transmission of PDCoV. The red dashed line indicates potential, but unknown, transmission of δ-CoVs from avian to mammalian species; the blue dashed line indicates potential transmission of PDCoV based on epidemiology or experimental studies.

Molecular epidemiology and diversity of PDCoVs

PDCoV was initially discovered in mainland China in 2015, but historical investigations reveal that it could have been a swine disease as early as 2004. Ninety-four of 719 swine diarrhea samples collected from 18 provinces in China between March 2016 and June 2018 were PDCoV-positive by RT-qPCR, according to a recent PDCoV surveillance study. The S genes of 11 PDCoV strains were determined in their entirety. The Chinese lineage was assigned to seven people. CH-WH-2017, on the other hand, was more closely related to the US/Japan/South Korea lineage. PDCoV has been found in 26 Chinese provinces, including all swine-producing areas, as of October 2021.

PDCoV-related diarrhea epidemics were discovered in Canada, South Korea, Thailand, Vietnam, and Laos from mid-March 2014 to January 2016. In addition, PDCoV has been circulating in Taiwan, Japan, Mexico, and Haiti since 2011, late 2013, 2015, and 2014, according to retrospective investigations. Although retrospective studies have been undertaken in Brazil and Spain to find CoVs in wild birds and pigs, no PDCoVs or PDCoV-like-CoVs have been detected in Europe, South America, Africa, or Australia.

The zoonotic potential of PDCoVs

Three zoonotic CoVs (SARS-CoV, MERS-CoV, and SARS-CoV-2) have posed a severe threat to public health and global security in the previous two decades. Also of zoonotic origin are HCoV-HKU1, HCoV-229E, HCoV-NL63, HCoV-OC43, and HECV-4408. A complete genome of a novel canine-feline recombinant alphacoronavirus (CCoV-HuPn-2018, GenBank accession no. MW591993.2) isolated from a child with pneumonia in Malaysia was first characterized in a recent study. Following this discovery, another investigation discovered and described a canine-feline recombinant alphacoronavirus in a medical team member that traveled to Haiti.

In November 2021, a study published the first indication that the PDCoV virus had spread from pigs to three Haitian children. The three children only had minor symptoms and were able to recover. These findings imply that PDCoV was transmitted from pigs to humans in at least two separate instances. PDCoV has only been shown to produce asymptomatic or moderate illness in humans, and it does not appear to pose a significant health concern to humans. In the future, however, continuous surveillance and seroprevalence investigations of PDCoV in humans, particularly those in direct contact with pigs, may provide certainty.

Conclusion

To further understand the ecology and development of deltacoronaviruses, more research into their genetic diversity in avian and mammalian hosts is required. Experiments on PDCoV interspecies transmission and host adaptation are also needed to assess the virus’s pathogenicity in different hosts.

Furthermore, seroprevalence investigations in pigs can provide valuable information about the global prevalence of PDCoV. Finally, to determine the impact of PDCoV on public health, ongoing surveillance and seroprevalence investigations in people are required. Pigs may require safe and efficient vaccines to prevent infection and to diminish the PDCoV gene pool, which contributes to spillovers, and humans may require vaccines if severe cases occur.

Journal reference:

  • Porcine Deltacoronaviruses: Origin, Evolution, Cross-Species Transmission and Zoonotic Potential, Fanzhi Kong, Qiuhong Wang, Scott P. Kenney, Kwonil Jung, Anastasia N. Vlasova, and Linda J. Saif, MDPI, 2022.01.09, https://doi.org/10.3390/pathogens11010079, https://www.mdpi.com/2076-0817/11/1/79/htm
Total
0
Shares
Share 0
Tweet 0
Pin it 0
Share 0
Medical Finance

Medical Finance

Related Posts

Study: Simple risk scores to predict hospitalization or death in outpatients with COVID-19. Image Credit: janews / Shutterstock.com

A validated risk-stratification system to manage COVID-19 outpatients

by Medical Finance
May 21, 2022
0

A rampant increase in the number of coronavirus disease (COVID-19) cases has made it difficult for healthcare providers around the...

Study: The SARS-CoV2 envelope is distinct from host membranes, exposes pro-coagulant lipids, and can be inactivated in vivo by surfactant-containing oral rinses. Image Credit: goffkein.pro/Shutterstock

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

by Medical Finance
May 21, 2022
0

In a recent study posted to the medRxiv* preprint server, an interdisciplinary team of researchers from different countries demonstrated the...

Study: Tuftsin: a natural molecule against SARS-CoV-2 infection. ​​​​​​​Image Credit: NIAID

The tetrapeptide tuftsin effectively impairs the binding of SARS-CoV-2 S1 to ACE2

by Medical Finance
May 21, 2022
0

Several prophylactic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being used across the globe to control the spread...

Study: Pharmacological inhibition of TBK1/IKKε blunts COVID-19 immunopathology. Image Credit: Corona Borealis Studio/Shutterstock

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

by Medical Finance
May 21, 2022
0

A study posted recently to the Research Square* preprint server and under consideration at a Nature Portfolio Journal suggested the...

Study: Transmission of SARS-CoV-2 from humans to animals and potential host adaptation. Image Credit: Tom Reichner/Shutterstock

Comparing the genomic landscapes of SARS-CoV-2 isolated from animal species relative to that in humans

by Medical Finance
May 21, 2022
0

A recent study available on the Research Square* preprint server and under consideration at a Nature Portfolio Journal identified six...

Study: Natural Trajectory of Recovery of COVID-19 Associated Olfactory Loss. Image Credit: E.Va/Shutterstock

Study measures recovery rate of SARS-CoV-2-induced olfactory loss

by Medical Finance
May 21, 2022
0

In a recent study posted to the medRxiv* preprint server, an interdisciplinary team of researchers from the Washington University, United...

Next Post
Study: Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting. Image Credit: Andreas Matzke/Shutterstock

SARS-CoV-2-specific immune responses elicited by inactivated COVID-19 vaccines

Malvern Panalytical expands pharmaceutical drug development solutions through the acquisition of Creoptix

Malvern Panalytical expands pharmaceutical drug development solutions through the acquisition of Creoptix

0 0 votes
Article Rating
Subscribe
Login
Notify of
guest
guest
0 Comments
Inline Feedbacks
View all comments

Support

  • Contact
  • Disclaimer
  • Home
  • Privacy Policy
  • Terms And Conditions

Categories

  • Coronavirus
  • Insights From Industry
  • Interviews
  • Mediknowledge
  • News
  • Thought Leaders
  • Whitepapers

More News

  • Study: SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells. Image Credit: stockklemedia/Shutterstock
    Study proposes SARS-CoV-2-encoded peptide presented by HLA-E may suppress inhibition of natural killer cells
  • Study: Identification of SARS-CoV-2 in different human tissues. Validation of immunohistochemical and qPCR techniques in paraffin-embedded tissues and cytology. Image Credit: PHOTOCREO Michal Bednarek/Shutterstock
    Scientists describe use of PCR in detecting SARS-CoV-2 in paraffine-embedded tissues
  • Home
  • Privacy Policy
  • Contact
  • Disclaimer
  • Terms And Conditions

© 2022 Medical Finance - Latest Financial and Business News

No Result
View All Result
  • Interviews
  • Mediknowledge
  • News
  • Insights From Industry
  • Coronavirus
  • Thought Leaders
  • Whitepapers
wpDiscuz
0
0
Would love your thoughts, please comment.x
()
x
| Reply