Saturday, May 14, 2022
No Result
View All Result
Medical Finance
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
No Result
View All Result
Medical Finance
No Result
View All Result
Home Coronavirus

Studying the immune response after COVID-19 vaccination using smartwatches and fitness bands

by Medical Finance
in Coronavirus
Study: Inter-individual variation in objective measure of reactogenicity following COVID-19 vaccination via smartwatches and fitness bands. Image Credit: Maridav/Shutterstock
9
SHARES
99
VIEWS
Share on FacebookShare on Twitter

The response to vaccination varies among individuals. Some vaccines cause adverse reactions, termed reactogenicity. Vaccine reactogenicity can cause physiological changes.

Study: Inter-individual variation in objective measure of reactogenicity following COVID-19 vaccination via smartwatches and fitness bands. Image Credit: Maridav/Shutterstock
Study: Inter-individual variation in objective measure of reactogenicity following COVID-19 vaccination via smartwatches and fitness bands. Image Credit: Maridav/Shutterstock

A new study published in npj Digital Medicine tracked these subtle physiological responses using smart wearable devices like smartwatches and fitness bands. This measurable evidence of reactogenicity can prove to be a useful surrogate for vaccine-induced immune response.

Vaccine reactogenicity

In the U.S., three coronavirus disease 2019 (COVID-19) vaccines have emergency use authorization, Pfizer-BioNTech two-dose mRNA vaccine, Moderna two-dose mRNA vaccine, and Janssen/Johnson & Johnson single-dose adenovirus-based vaccine. Several studies have established the efficacies of these vaccines.

The individual immune responses to vaccines vary, including the COVID-19 vaccines. Currently, the non-invasive method to identify an individual’s response to vaccination is through self-reporting of the side effects.

According to the Centers for Disease Control and Prevention (CDC), 69% of individuals (out of 1.9 million) reported systemic side effects after the second dose of an mRNA vaccine. The side effects include systemic inflammation, fatigue, muscle pain, chills, fever, and joint pain. Around 25.6% to 53.9% of individuals had side effects the day following their 2nd dose. The side effects experienced after the booster dose were less than those after the second dose but more than those after the first dose.

The correlation between post-vaccination reactogenicity symptoms and an immune response is debated. One study has identified a direct correlation between the period between the first and second vaccine dose, reactogenicity, and the humoral immune response. Another study has shown a correlation between physiological changes measured using a smart ring and around 30-day antibody levels.

Hypothesis

This study hypothesized that there are measurable markers of vaccine reactogenicity. These biomarkers are digital and objective. Moreover, they can be identified by detecting subtle changes in the normal resting heart rate (RHR) of an individual.

Furthermore, post-vaccination behavioral changes in an individual can be investigated by measuring changes in their routine sleep and activity. The characteristics of an individual and the vaccine can be explored to see if they influence reactogenicity. Thus, a correlation can be established between changes in RHR and COVID-19 infection status or vaccination status.

DETECT study

This was an observational, longitudinal, prospective, direct-to-participant, app-based study titled Digital Engagement and Tracking for Early Control and Treatment (DETECT) study. Daily data were collected from smart wearable devices. The data collection period included the two weeks before and after each vaccination dose. Data was collected from 7,298 participants who reported receiving at least one dose of the vaccine. A total of 6,803 participants received both doses of an mRNA vaccine. Only 437 participants received the Johnson & Johnson single-dose adenovirus-based vaccine and therefore, were excluded from this study.

Post-vaccination changes in RHR and behavioral changes

For the analysis of changes in RHR, 5764 (78%) participants were included. Of these, 314 (5.5%) had prior COVID-19 infection, 2,388 (42%) received the Moderna vaccine, and 3,286 (58%) received the Pfizer-BioNTech vaccine.

For the analysis of behavioral changes, 4,628 (63%) participants contributed adequate data to assess changes in activity, and 5,691 (78%) participants contributed adequate data to assess changes in sleep.

The RHR increased from the respective individual baseline after vaccination for most individuals – 71% after the first dose and 76% after the second dose. It peaked on day 2 and returned to baseline by day 6. The average RHR did not normalize until day 4 after the first dose and day 6 after the second dose.

For 47% of participants, the increase in RHR was one standard deviation above or 68% higher than their normal daily pattern after the second vaccine dose.

Prior COVID-19 infection correlated with a higher RHR increase after the first vaccine dose compared to those without prior infection. However, these participants showed no difference in RHR after the second dose. The changes in RHR for individuals who received the Moderna vaccine were higher than for those who received the Pfizer-BioNTech vaccine. This difference was observed after the first and second doses.

After the first dose, females showed a higher RHR increase. Also, participants less than 40 years old showed a higher RHR increase after the second dose.

Normal activity and sleep patterns were minimally affected by the first dose of the vaccine. However, on that day after the second vaccine dose, there was a significant decrease in activity and increase in sleep, relative to baseline. This returned to baseline by day 2. 

Intriguingly, changes in sleep and activity did not correlate with changes in RHR. 

Conclusion

COVID-19 vaccination resulted in subtle but significant changes in RHR. There was substantial interindividual variability in RHR increase that could be correlated with the vaccine type or prior COVID-19 infection, characteristics associated with reactogenicity and immune response. Digital tracking can be used as a surrogate for vaccine-induced immune response.

Total
0
Shares
Share 0
Tweet 0
Pin it 0
Share 0
Medical Finance

Medical Finance

Related Posts

Study: Levels of SARS-CoV-2 Antibodies Among Fully-Vaccinated Individuals With Delta or Omicron Variant Breakthrough Infections: A Prospective Cohort Study. Image Credit: petovarga/Shutterstock

Risk of breakthrough infections by SARS-CoV-2 Omicron and Delta variants in fully vaccinated adults

by Medical Finance
May 14, 2022
0

In a recent study posted to the Preprints with The Lancet* server, researchers determined the risk of breakthrough infections by...

Study: Dynamics of Neutralizing Antibodies and Binding Antibodies to Domains of SARS-CoV-2 Spike Protein in COVID-19 Survivors. Image Credit: Kateryna Kon / Shutterstock.com

Neutralizing antibody levels to different SARS-CoV-2 epitopes fluctuate over time

by Medical Finance
May 14, 2022
0

The potential utility of neutralizing antibodies as anti-viral treatments have led many researchers to study the humoral immune response to...

Study: Venous Thromboembolism in Ambulatory Covid-19 patients: Clinical and Genetic Determinants. Image Credit: Kateryna Kon / Shutterstock.com

Clinical determinants of post-COVID-19 thromboembolism

by Medical Finance
May 14, 2022
0

Various case and hospital-based studies have shown a high risk of venous thromboembolism (VTE) in patients with severe coronavirus disease...

Study: Associations between persistent symptoms after mild COVID-19 and long-term health status, quality of life, and psychological distress. Image Credit: Starocean/Shutterstock

Study identifies implications of long-COVID on long term physical and mental health

by Medical Finance
May 14, 2022
0

A recent study published in the Influenza and Other Respiratory Viruses journal assessed the characteristics of persistent coronavirus disease 2019...

Study: The rise and fall of SARS-CoV-2 variants and the emergence of competing Omicron lineages. Image Credit: Adao / Shutterstock.com

Research suggests SARS-CoV-2 viral accessory proteins may play significant role in viral evolution

by Medical Finance
May 14, 2022
0

Early on in the coronavirus disease 2019 (COVID-19) pandemic, many governments around the world enacted costly and restrictive measures to...

Study: Early detection of SARS-CoV-2 variants using traveler-based genomic surveillance at four US airports. Image Credit: Thanakorn.P / Shutterstock.com

U.S. traveler-based genomic surveillance provided early SARS-CoV-2 variant detection

by Medical Finance
May 14, 2022
0

During the early phases of the coronavirus disease 2019 (COVID-19) pandemic, the speed and approach of different countries' responses to...

Next Post
Study: SARS-CoV-2 Infections in Professional Orchestra and Choir Musicians – A Prospective Cohort Study. Image Credit: Skreidzeleu/Shutterstock

Incidence of SARS-CoV-2 infections in orchestra and choir musicians

Study: NRP1 and furin as putative mediators of SARS-CoV-2 entry into human brain cells. Image Credit: Kateryna Kon/Shutterstock

Researchers discover mechanism behind SARS-CoV-2 entry into the brain

0 0 votes
Article Rating
Subscribe
Login
Notify of
guest
guest
0 Comments
Inline Feedbacks
View all comments

Support

  • Contact
  • Disclaimer
  • Home
  • Privacy Policy
  • Terms And Conditions

Categories

  • Coronavirus
  • Insights From Industry
  • Interviews
  • Mediknowledge
  • News
  • Thought Leaders
  • Whitepapers

More News

  • Disability 620x480
    Covid still threatens millions of Americans. Why are we so eager to move on?
  • Study: Risk of Second Allergic Reaction to SARS-CoV-2 Vaccines A Systematic Review and Meta-analysis. Image Credit: Rido/Shutterstock
    Low risk of second allergic reaction after SARS-CoV-2 vaccination
  • Home
  • Privacy Policy
  • Contact
  • Disclaimer
  • Terms And Conditions

© 2022 Medical Finance - Latest Financial and Business News

No Result
View All Result
  • Interviews
  • Mediknowledge
  • News
  • Insights From Industry
  • Coronavirus
  • Thought Leaders
  • Whitepapers
wpDiscuz
0
0
Would love your thoughts, please comment.x
()
x
| Reply