Thursday, May 19, 2022
No Result
View All Result
Medical Finance
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
  • Home
  • News
  • Interviews
  • Mediknowledge
  • Insights From Industry
  • Thought Leaders
  • Coronavirus
  • Whitepapers
No Result
View All Result
Medical Finance
No Result
View All Result
Home Coronavirus

Researchers investigate whether influenza impacted the epidemiological dynamics of SARS-CoV-2

by Medical Finance
in Coronavirus
Study: Estimating the impact of influenza on the epidemiological dynamics of SARS-CoV-2. Image Credit: Dotted Yeti/Shutterstock
9
SHARES
101
VIEWS
Share on FacebookShare on Twitter

There has been evidence from past pandemics about co-circulating pathogens that may play a role in understanding the epidemiology of coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Study: Estimating the impact of influenza on the epidemiological dynamics of SARS-CoV-2. Image Credit: Dotted Yeti/ShutterstockStudy: Estimating the impact of influenza on the epidemiological dynamics of SARS-CoV-2. Image Credit: Dotted Yeti/Shutterstock


Scientific evidence in the past has supported theories supporting the increased spread of the influenza virus due to co-infection with other respiratory viruses during the 1918 influenza pandemic that resulted in multiple waves of the pandemic. Interestingly, as per recent evidence, a respiratory viral co-infection (particularly with influenza viruses) can up-regulate the expression of angiotensin-converting enzyme 2 (ACE2), the key receptor used by SARS-CoV-2 to bind to human cells, replicate and cause infection in the respiratory epithelium and later cause severe damage to the lungs in certain cases. Furthermore, this up-regulation was demonstrated experimentally to increase the infectivity of SARS-CoV-2 in laboratory mice co-infected with the influenza A virus.


Researchers wanted to test the co-infection and induced infectivity hypothesis that has been unexplored territory to date. Their study to test and verify the co-infection hypothesis was published recently in the journal PeerJ. They developed a semi-mechanistic, population-based model of SARS-CoV-2 transmission and COVID-19 mortality. They considered the population of four European countries, Belgium, Italy, Norway, and Spain. They used likelihood-based statistical inference methods, using mortality incidence data to study the co-infection dynamics of COVID-19 and influenza.


Study details


Researchers collected infection data for the influenza virus based on the weekly numbers of samples tested and those who tested positive for any influenza virus from the FluNet database, compiled by the World Health Organization (WHO). They also collected syndromic data on the weekly incidence rate of influenza-like illnesses (ILI) in parallel from the FluID database, also compiled by the WHO.


On the other hand, data on the daily number of deaths caused by SARS-CoV-2 were inferred from the date of death, which was available from national public health public institutes in Belgium, Italy, and Spain (Instituto de Salud Carlos III). In Norway, the mortality data were available from the worldwide database compiled by the European Center for Disease Control and Prevention (CDC).


The researchers formulated a semi-mechanistic variant of the standard Susceptible–Exposed–Infected–Recovered transmission model, using the method of stages to allow for realistic distributions of the latent, infectious, and onset-to-death periods from the data collected. Researchers used multiple statistical inference methods based on iterated filtering to fit with mortality incidence data in the four countries to systematically test a range of assumptions about the impact of influenza.


The results indicated that, during the co-circulation period, influenza was associated with an average 1.8–3.4-fold (uncertainty range across countries: 1.1 to 5.0) population-level increase in SARS-CoV-2 transmission.


As per data from previous studies, researchers found robust and consistent evidence that non-pharmacological control measures markedly reduced the transmission of SARS-CoV-2. They also found consistent evidence suggesting that co-circulation of influenza transiently facilitated the transmission of SARS-CoV-2 in the early phase of the epidemic in Europe.


Implication


In the light of recent discoveries regarding the structural modifications of the SARS-COV-2 and its impact on COVID-19, it is likely that the pandemic may soon be converting into an endemic. In such a scenario, the potential interactions of SARS-CoV-2 with other respiratory pathogens, particularly respiratory viruses, may become another rising concern for public health authorities. In this context, this study adds useful insight into the co-infection dynamics of the two respiratory viruses – influenza and COVID-19, consistent with several experimental and epidemiological evidence lines.

Total
0
Shares
Share 0
Tweet 0
Pin it 0
Share 0
Medical Finance

Medical Finance

Related Posts

Study: Relating SARS-CoV-2 Variants Using Cellular Automata Imaging. Image Credit: Mediantone/Shutterstock

Cellular automata imaging-based classification of SARS-CoV-2 variants

by Medical Finance
May 19, 2022
0

In a pre-print study posted to Research Square* and currently under review at Scientific Reports, researchers classified and grouped severe acute...

Study: Persistence of residual SARS-CoV-2 viral antigen and RNA in tissues of patients with long COVID-19. Image Credit: ANDREI_SITURN/Shutterstock

Study reports persistent SARS-CoV-2 lingering within tissues of patients with long COVID

by Medical Finance
May 19, 2022
0

In a recent study posted to Research Square*, researchers investigated whether residual severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens...

Study: Characterization of Bombali Virus, a New Bat Filovirus. Image Credit: James Sakaguchi/Shutterstock

Foundational characterization of a new bat-borne ebolavirus and its potential as a human pathogen

by Medical Finance
May 19, 2022
0

There are many documented cases of pathogens from animals jumping species resulting in a disease that affects humans. One of...

Study: Understanding the immunological landscape of England during SARS-CoV2 Omicron variant wave. Image Credit: Adao/Shutterstock

Immunological landscape of England during Omicron-driven SARS-CoV-2 wave

by Medical Finance
May 19, 2022
0

In a recent study posted to the medRxiv* preprint server, researchers determined the immunological landscape of England throughout the severe acute...

Study: Modular capsid decoration boosts adenovirus vaccine-induced humoral and cellular immunity against SARS-CoV-2. Image Credit: hedgehog94/Shutterstock

Study explores the boosting of SARS-CoV-2 adenovirus vaccine-induced immunity by capsid decoration

by Medical Finance
May 19, 2022
0

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that decorating the capsid surface of adenovirus (Ad)...

Study: Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection. Image Credit: Terelyuk/Shutterstock

Study shows SARS-CoV-2 hijacks mitochondrial transcriptional machinery resulting in organ failure and death

by Medical Finance
May 19, 2022
0

In a recent study posted to the bioRxiv* pre-print server, researchers studied the effects of severe acute respiratory syndrome coronavirus...

Next Post
TetraScience announces 300% ARR growth and 2021 achievements; prepares for next phase of growth

Origin, evolution and ecological relationships of yeasts

Study: SARS-CoV-2 Omicron-specific mRNA vaccine induces potent and broad antibody responses in vivo. Image Credit: angellodeco / Shutterstock.com

Researchers develop novel anti-SARS-CoV-2 Omicron vaccine candidate

0 0 votes
Article Rating
Subscribe
Login
Notify of
guest
guest
0 Comments
Inline Feedbacks
View all comments

Support

  • Contact
  • Disclaimer
  • Home
  • Privacy Policy
  • Terms And Conditions

Categories

  • Coronavirus
  • Insights From Industry
  • Interviews
  • Mediknowledge
  • News
  • Thought Leaders
  • Whitepapers

More News

  • bacteria Sebastian Kaulitzki 46826fb7971649bfaca04a9b4cef3309 620x480
    Gut bacteria transfer genes through sex to take vitamin B12, study shows
  • Study: SARS-CoV-2 Causes a Significant Stress Response Mediated by Small RNAs in the Blood of COVID-19 Patient. Image Credit: creativeneko/Shutterstock
    Study finds SARS-CoV-2 infection caused significant changes in the levels of stress associated small RNAs
  • Home
  • Privacy Policy
  • Contact
  • Disclaimer
  • Terms And Conditions

© 2022 Medical Finance - Latest Financial and Business News

No Result
View All Result
  • Interviews
  • Mediknowledge
  • News
  • Insights From Industry
  • Coronavirus
  • Thought Leaders
  • Whitepapers
wpDiscuz
0
0
Would love your thoughts, please comment.x
()
x
| Reply